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4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2- a ]pyrimidine-3-carboxylic acids

Identifieur interne : 003446 ( Main/Exploration ); précédent : 003445; suivant : 003447

4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2- a ]pyrimidine-3-carboxylic acids

Auteurs : I. V. Ukrainets [Ukraine] ; N. L. Bereznyakova [Ukraine] ; I. A. Turaibei [Ukraine, Russie]

Source :

RBID : ISTEX:52550D902E9F63015B6CDC0D98F1B3379565D73C

English descriptors

Abstract

Abstract: Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.

Url:
DOI: 10.1007/s10593-008-0012-x


Affiliations:


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